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目的 研究血清白介素-6(IL-6)和降钙素原(procalcitonin,PCT)的动态变化对急诊老年脓毒性休克患者的病情和预后的评估意义.方法 选择华北石油管理局总医院井下医院老年脓毒性休克患者128例,分别于入院后第1、3、7天给与IL-6和PCT等检查,并给与APACHEⅡ评分(acute physiology and chronic health evaluation Ⅱ).随访28 d,根据预后患者分为死亡组和存活组,分别比较死亡组和存活组第1、3、7天IL-6,PCT的区别;分析TL-6和PCT与APACHE Ⅱ评分的相关性.结果 死亡组第1天和第3天的IL-6和PCT与存活组比较差异无统计学意义(P＞0.05),第7天的IL-6和PCT均大于存活组,第7天IL-6和PCT与APACHE Ⅱ评分呈正相关(P＜0.05).结论 IL-6和PCT对急诊老年脓毒性休克患者的病情和预后具有重要的评估意义,IL-6和PCT持续处于高水平状态提示患者预后不佳.“,”Objective To study prognosis value of dynamic changes of procalcitonin and IL-6 in emergency elderly patients with septic shock.Methods 128 elderly septic shock patients were selected in the Department of Jingxia Hospital,General Hospital of North China Petroleum Administration Bureau,PCT and IL-6 were detected in 1,3,7 days after admission.Acute Physiology and Chronic Health Evaluation lⅡ scores were assessed.Followed-up period was 28 days,according to the prognosis of patients,the patients were divided into the death group(38 cases) and survival group (90 cases),the difference of PCT,IL-6 were respectively compared between the 2 groups in 1,3,7 days.The correlation of IL-6 and PCT with APACHE Ⅱ score were analyzed.Results PCT and IL-6 levels had no significant difference between the death group and survival group (P ＞0.05) in 1 and 3 days,IL-6 and PCT in death group were greater than these in survival group in 7th days,IL-6 and PCT were positively correlated with APACHE Ⅱ score (P ＜ 0.05).Conclusion IL-6 and PCT had important prognosis value for emergency elderly patients with septic shock.IL-6 and PCT continued remain at a high level indicated the patients with poor prognosis.