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分析深圳市南山区人民医院粪肠球菌感染患者的临床资料,探讨引起感染的危险因素,为防治耐利奈唑胺粪肠球菌感染提供临床参考。选取2010年1月—2015年9月在深圳市南山区人民医院住院的165例粪肠球菌感染患者,根据药敏结果分为利奈唑胺敏感组(103例)和利奈唑胺中介/耐药组(62例)。165例粪肠球菌主要来源于中段尿培养,占53.94%,其次为伤口分泌物培养(21.82%)、血培养(6.06%);科室分布以泌尿外科和肝胆外科为主,分别占35.76%和9.70%。单因素分析显示,碳青霉烯类抗生素暴露、留置尿管与感染相关。Logistic回归分析进一步明确碳青霉烯类抗生素暴露、留置尿管为耐利奈唑胺粪肠球菌感染的危险因素,提示应严格掌握碳青霉烯类抗生素的适应证,加强医院内感染的控制管理。
To analyze the clinical data of patients with Enterococcus faecalis infection in Nanshan District People’s Hospital of Shenzhen, to explore the risk factors of infection and to provide clinical reference for the prevention and treatment of linezolid infection with linezolid. One hundred and sixty-five patients with E. faecalis inpatients hospitalized in Nanshan District People’s Hospital of Shenzhen from January 2010 to September 2015 were divided into linezolid sensitive group (103 cases) and linezolid mediator / resistant Group (62 cases). 165 cases of Enterococcus faecalis mainly originated from the mid-stage urinary culture, accounting for 53.94%, followed by wound secretion culture (21.82%) and blood culture (6.06%); Department of Urology and hepatobiliary surgery dominated, accounting for 35.76% 9.70%. Univariate analysis showed that carbapenem antibiotic exposure, indwelling catheter and infection related. Logistic regression analysis further clarified that carbapenem antibiotic exposure and indwelling catheter were the risk factors of linezolid infection with linezolid, suggesting that the indication of carbapenem should be strictly controlled and the management and control of nosocomial infection should be strengthened .