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目的探讨Delta样配体4(DLL4)和血管内皮生长因子(VEGF)蛋白在乳腺癌组织中的表达及意义。方法应用免疫组织化学法检测60例乳腺癌组织及20例癌旁正常乳腺组织中DLL4和VEGF蛋白的表达,分析两者与乳腺癌患者临床病理学特征的关系。结果 DLL4和VEGF蛋白在乳腺癌组织中的表达高于癌旁正常组织(P<0.05)。DLL4蛋白的表达与乳腺癌的组织学分级、临床分期、淋巴结转移、肿瘤直径有关(P<0.05),VEGF蛋白的表达与乳腺癌的组织学分级、临床分期、淋巴结转移均有关(P<0.05),两者在乳腺癌组织中的表达呈正相关(r=0.462,P<0.001)。结论 DLL4及VEGF蛋白表达与乳腺癌的浸润、转移密切相关,两者可能具有协同作用。
Objective To investigate the expression and significance of Delta-like ligand 4 (DLL4) and vascular endothelial growth factor (VEGF) protein in breast cancer. Methods Immunohistochemistry was used to detect the expression of DLL4 and VEGF protein in 60 cases of breast cancer tissues and 20 cases of normal breast tissues. The relationship between them and the clinicopathological characteristics of breast cancer patients was analyzed. Results The expression of DLL4 and VEGF protein in breast cancer tissues was higher than that in adjacent normal tissues (P <0.05). The expression of DLL4 protein was correlated with histological grade, clinical stage, lymph node metastasis and tumor diameter in breast cancer (P <0.05), and VEGF protein expression was correlated with histological grade, clinical stage and lymph node metastasis ), The expression of which in breast cancer was positively correlated (r = 0.462, P <0.001). Conclusion The expressions of DLL4 and VEGF are closely related to the infiltration and metastasis of breast cancer, and they may have synergistic effects.