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膜性肾病(MN)为成年人肾病综合征常见病理类型,治疗不当可最终进展为终末期肾病.膜性肾病从病因上可分为特发性膜性肾病(IMN)和继发性膜性肾病,而特发性膜性肾病约占膜性肾病的75％,所以在临床工作中区分特发性与继发性是诊断和治疗的重要前提.对特发性膜性肾病发病机制的研究至今尚不明确,但近年来一些研究者针对膜性肾病肾小球足细胞抗原与循环中对应抗体,而形成的免疫复合物有深入探讨.“,”Membranous nephropathy (MN) is a major cause of nephrotic syndrome in adults,and the inappropriate treatment may progress to end-stage renal disease.We know that membranous nephropathy can be divided into idiopathic membranous nephropathy (IMN) and secondary membranous nephropathy (SMN).The etiology of approximately 75％ of MN cases is idiopathic.In clinical work,we should distinguish IMN from SMN,which is the important premise for the diagnosis and treatment of MN.The definite pathogenesis of IMN remains unknown.However,some researchers have focused on the formation of immune complexes in the pathogenesis of MN in recent years.