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骨硬化蛋白(sclerostin),曾称硬骨素,由SOST基因编码,是一种分泌型糖蛋白。体内研究证明,骨硬化蛋白特异性地表达于骨细胞(osteocyte)中,通过作用于成骨细胞而在骨代谢中起重要作用。骨硬化蛋白基因(SOST)的表达受应力作用、激素、氧浓度等因素的影响。拮抗骨硬化蛋白可以缓解骨质疏松的症状,这为临床治疗骨质疏松等疾病提供了新思路与新方法。本文在介绍骨硬化蛋白的表达定位与分子结构的基础上,就其参与骨代谢的最新研究进展做一综述。
Sclerostin, once called sclerostin, is encoded by the SOST gene and is a secreted glycoprotein. In vivo studies have demonstrated that osteosclerosis proteins are specifically expressed in osteocytes and play an important role in bone metabolism by acting on osteoblasts. The expression of osteosclerosis gene (SOST) is affected by stress, hormone and oxygen concentration. Antagonizing sclerostin can relieve the symptoms of osteoporosis, which provides new ideas and new methods for the clinical treatment of diseases such as osteoporosis. Based on the introduction of the expression and molecular structure of osteosclerosis, this review summarizes recent progress in its involvement in bone metabolism.