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目的评价顺铂、5-氟尿嘧啶区域性持续动脉灌注化疗对口腔癌的疗效及安全性。方法入选口腔癌患者82例,随机分为对照组40例和试验组42例。对照组用肌内注射平阳霉素8 mg,每日1次;试验组以微量注射泵持续动脉灌注顺铂100 mg·m-224 h,第1天+5-氟尿嘧啶1000 mg·m-2持续灌注72 h,21 d为一个化疗周期,2组患者均化疗3个周期。比较2组患者的客观反应率(ORR)及不良反应发生情况。结果对照组客观缓解率为57.5%,显著低于试验组的78.6%(P<0.05)。试验组发生恶心呕吐8例(19.05%),骨髓抑制1例(2.38%);对照组分别为14例(35.00%),3例(7.50%),试验组总体不良反应发生率为42.50%,显著低于对照组21.43%(P<0.05)。结论顺铂、5-氟尿嘧啶区域性持续动脉灌注化疗对口腔癌的疗效显著,不良反应发生率低。
Objective To evaluate the efficacy and safety of cisplatin and 5-fluorouracil regional continuous intraarterial chemotherapy in oral cancer. Methods Eighty-two patients with oral cancer were randomly divided into control group (n = 40) and experimental group (n = 42). The control group was injected intramuscularly with 8 mg of pingyangmycin once daily. The experimental group was given continuous infusion of cisplatin (100 mg · m-224 h) with microinjection pump and the first day with 5-fluorouracil 1000 mg · m-2 72 h infusion, 21 d for a chemotherapy cycle, two groups of patients were chemotherapy for 3 cycles. The objective response rate (ORR) and the incidence of adverse reactions in the two groups were compared. Results The objective response rate was 57.5% in the control group, which was significantly lower than 78.6% in the experimental group (P <0.05). The incidence of nausea and vomiting in experimental group was 8 cases (19.05%) and bone marrow suppression was 1 case (2.38%). The control group was 14 cases (35.00%) and 3 cases (7.50% Significantly lower than the control group 21.43% (P <0.05). Conclusion cisplatin, 5-fluorouracil regional continuous intra-arterial chemotherapy has a significant effect on oral cancer, the incidence of adverse reactions is low.