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【目的】探讨围生期足月儿、早产儿不同程度黄疸对凝血四项水平影响,为临床早期干预异常的凝血象提供依据。【方法】采398例围生儿黄疸血浆,测凝血酶原时间PT(prothrombin time)、活化部分凝血活酶时间APTT(activated partial thromboplastin time)、凝血酶时间TT(thrombin time)、纤维蛋白原Fib(fibrinogen)。【结果】胆红素越高,APTT、PT、TT延长,Fib含量降低,早产与足月儿各对应组比较,其APTT、PT、TT均明显延长,Fib含量低。新生儿黄疸越明显,出血倾向发生率越高(P<0.01)。【结论】对新生儿高胆红素血症凝血功能监测是必需的,尤其中重度黄疸,给以注射维生素K1等早期干预异常凝血象。
【Objective】 To investigate the effects of different levels of jaundice on the four levels of clotting during perinatal period of full-term infants and premature infants, so as to provide the basis for early clinical clotting abnormalities. 【Methods】 398 cases of perinatal jaundice plasma were collected. Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen Fib (fibrinogen). 【Results】 The results showed that the higher the bilirubin, the longer the APTT, the shorter the PT and the TT, the lower the Fib content. The APTT, PT and TT were significantly prolonged and the Fib content was lower in preterm and full-term infants. Neonatal jaundice more obvious, the higher the incidence of bleeding tendency (P <0.01). 【Conclusion】 Neonatal hyperbilirubinemia coagulation function monitoring is necessary, especially in moderate and severe jaundice, to give early intervention such as vitamin K1 abnormal coagulation.