Magnetic Stimulation Accelerating Rehabilitation of Peripheral Nerve Injury

来源 :华中科技大学学报(医学英德文版) | 被引量 : 0次 | 上传用户:tonyyuhua
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Summary: The effect of magnetic stimulation (MS) on sciatic nerve injury was observed. After sciat-ic nerve was crushed in 40 Sprague Dawley (SD) rats, one randomly selected group (group D) was subjected, from the 4th day post-operatively to 3 min of continuous 70 % of maximum output of MS daily for 8 weeks. The other group (group E) served as a control group. The nerve regeneration and motor function recovery were evaluated by walking track analysis (sciatic function index, SFI; toe spreading reflex, TSR), electrophysiological, histological and acetylcholineesterase histochemistry.The SFI in the group D was greater than in the group E with the difference being statistically signifi cant (P<0. 01). TSR reached its peak on the 4th day in the group D and on the 10th day in the group E respectively. The amplitude and velocity of MCAP and NCAP in the group D was greater than in the group E with the difference being statistically significant (P<0. 01), while the latency and duration of MCAP and NCAP in the group D were less than in the group E with the differencebeing also statistically significant (P<0. 01). Histological examination showed the mean axon countabove the lesion for thick myelinated fibers (>6.5 μm) in the group D was greater than in the con-trol group with the difference being statistically significant (P<0. 01), while the mean axon countbelow the lesion for thick myelinated fibers was less than that in the group E with the difference be-ing statistically significant (P<0. 01). The mean axon count above the lesion for thin myelinatedfibers (2-6.5 μm) in the group D was greater than that in the group E with the difference being sta-tistically significant (P<0. 05), while the mean axon count below the lesion for thin myelinated in the group D was greater than that in the group E with the difference being statistically significant (P<0. 01). Acetylcholine esterase examination showed that the MS could significantly increase thenumber of the motor neurons. There was no significant difference in the number of the motor neu-rons between the treatment side and the normal side (P>0. 05). It can be concluded that MS can en-hance functional recovery and has a considerable effect in the treatment of the peripheral nerve in jury.
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