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掌跖角化-牙周破坏综合征又名Papillon-Lefèvre综合征(Papillon-Lefèvre syndrome,PLS)是一种常染色体隐性遗传性疾病,PLS在临床上较为罕见,由法国人Papillon和Lefèvre在1924年发现本病并首次报告[1]。该病在人群中的发病率为百万分之一至百万分之四[2]。男女患病机会均等,未见种族特异性。遗传倾向于近亲结婚的比例大约是1/3[3]。该病的特征是掌趾皮肤过度角化、皲裂和脱屑,早期快速进展的牙周组织破坏严重,牙槽骨吸收,常导致乳牙和恒牙的过早脱落[4]。本文就哈医科大学附属第二临床医学院牙周科发现的1例掌跖角化-牙周综合症进行报道,并对
Palmoplantar keratosis - Periodontal destruction syndrome, also known as Papillon-Lefèvre syndrome (Papillon-Lefèvre syndrome, PLS) is an autosomal recessive disease, PLS is relatively rare in the clinic by the French Papillon and Lefèvre 1924 found the disease and the first report [1]. The incidence of this disease in the population is one millionth to four parts per million [2]. There is no racial specificity for the equal opportunity of illness for men and women. Genetically predisposed to the proportion of married relatives is about 1/3 [3]. The disease is characterized by hyperkeratosis, chapped and desquamated skin of the toe, early destruction of the rapidly progressing periodontal tissue, and alveolar bone resorption, often leading to premature deciduous deciduous teeth and permanent teeth [4]. This article reports the clinical observation of 1 case of palmoplantar keratosis - periodontal syndrome found in the periodontal department of the Second Affiliated Hospital of Harbin Medical University