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目的探讨肺炎、腹泻患儿血清维生素A状况及其影响因素。方法采用微量荧光法测定60例肺炎、85例腹泻患儿和100例健康儿童血清维生素A值,进行多元回归分析。结果肺炎、腹泻患儿的血清维生素A值分别为(1.0±0.4)μmol/L、(0.7±0.4)μmol/L,均明显低于健康儿童的(1.9±0.6)μmol/L(P﹤0.01)。两组亚健康维生素A缺乏(SVAD)发病率分别为28.3%、54.1%,均明显高于健康儿童的1.0%(P﹤0.005)。多因素分析表明,肺炎组血清维生素A低的危险因素为发热、病情重、家居农村,腹泻组血清维生素A低的危险因素为年龄小、高热、脱水、日大便次数多。结论肺炎、腹泻患儿血清维生素A水平低于健康儿童。年龄小、农村患儿、发热和脱水与体内维生素A状况关系较密切。
Objective To investigate the status of serum vitamin A in children with pneumonia and diarrhea and its influencing factors. Methods The serum levels of vitamin A in 60 cases of pneumonia, 85 cases of children with diarrhea and 100 cases of healthy children were measured by using microfluorescence. Multiple regression analysis was performed. Results The serum vitamin A levels in children with pneumonia and diarrhea were (1.0 ± 0.4) μmol / L and (0.7 ± 0.4) μmol / L, respectively, which were significantly lower than those in healthy children (1.9 ± 0.6) μmol / L ). The incidences of sub-health vitamin A deficiency (SVAD) in both groups were 28.3% and 54.1%, respectively, which were significantly higher than 1.0% of healthy children (P <0.005). Multivariate analysis showed that the risk factors for low serum vitamin A in patients with pneumonia were fever and severe illness. The risk factors for low serum vitamin A in rural residents and diarrhea group were younger age, hyperthermia, dehydration and more diarrhea. Conclusions The level of serum vitamin A in children with pneumonia and diarrhea is lower than that in healthy children. Small age, rural children, fever and dehydration and vitamin A status more closely related.