Objective:To compare the anti-atherosclerotic effects of two different extracts from the leaves of Mallotus fiiretianus by using rat model of atherosclerosis.Methods:The air-flriefl powdered Mallotus fiiretianus leaves were extracted with ethanol and then evaporated.The ethanol extract was experienced Diaion HP-20 CC with a gradient of MeOH and H_2O(50:50,100:0,v/v) and two fractions,Mallotus fiiretianus A(Mf A) and Mallotus fiiretianus B(MfB) were obtained.RaLs were divided into control,atherosclerosis and vitamin E,Mf A and Mf B treated groups.Atherosclerotic model was established by administering u loading dose of vitamin D_3 and feeding standard diet enriched with 2%cholesterol,0.5%porcine chelate,0.2%methimazole,5%sugar,10%pork fat. Vitamin E(0.20 g/kg),Mf A(0.053 g/kg),Mf B(0.057 g/kg)(with the potential) were administered to interfere with the development of atherosclerosis.After 9 weeks,rats were sacrificed and the blood lipid as well as composition of bile was examined.In addition,the thoracic aorta was harvested to evaluate histological changes and the intima-media thickness ratio.Results: Atherosclerosis model was successfully established,administration of vitamin E,Mf A and Mf B increased excretion of total bilirubin in bile,decreased triglycridc(TO),total cholesterol(TC), low density lipoprotein-cholesterol(LDL-C) level,enhanced ratio of high density lipoprotein-cholesterol and LDL-C in blood,improved histological changes and diminished intimamedia thickness ratio of thoracic aorta in atherosclerotic rats.As for the difference in antiatherosclerotic effects between Mf A and MfB,Mf A may be more powerful in declining TG level and Mf B may be more effective in decreasing TC level.Conclusions:The two different extracts. Mf A and Mf B can prevent the development of atherosclerosis.In detail,Mf A is more effective in regulating TG level and Mf B is more powerful in modulating TC.level in atherosclerotic rats. Objective: To compare the anti-atherosclerotic effects of two different extracts from the leaves of Mallotus fiiretianus by using rat model of atherosclerosis. Methods: The air-flriefl powdered Mallotus fiiretianus leaves were extracted with ethanol and then eva. The ethanol extract was experienced Diaion HP-20 CC with a gradient of MeOH and H 2 O (50:50, 100: 0, v / v) and two fractions, Mallotus fiiretianus A (Mf A) and Mallotus fiiretianus B and vitamin E, Mf A and Mf B treated groups. Atherosclerotic model was established by administering u loading dose of vitamin D_3 and feeding standard diet enriched with 2% cholesterol, 0.5% porcine chelate, 0.2% methimazole, 5% sugar, 10% pork fat. Vitamin E (0.20 g / kg), Mf A (0.053 g / kg), Mf B (0.057 g / kg) with the potential were interfere with the development of atherosclerosis. After 9 weeks, rats were sacrificed and the blood lipid as well as composition as bile was investigations.In addi tion, the thoracic aorta was harvested to evaluate histological changes and the intima-media thickness ratio. Results: Atherosclerosis model was successfully established, administration of vitamin E, Mf A and Mf B increased excretion of total bilirubin in bile, decreased triglycridc (TO) , total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) level, enhanced ratio of high density lipoprotein-cholesterol and LDL-C in blood, improved histological changes and diminished intimamedia thickness ratio of thoracic aorta in atherosclerotic rats. Mf A and Mf B can prevent the development of atherosclerosis. detail, Mf A is more effective in regulating TG level and Mf B is more powerful in modulating TC. level in atherosclerotic rats.