40只地鼠随机分为两组 ,实验组 :2 0只腹腔接种副结核杆菌 ;对照组 :2 0只分别接种生理盐水和死菌 (各 10只 ) ,8个月后处死动物 ,作病理学观察 .结果 :实验组 80 % (16 /2 0 )的地鼠出现肉芽肿性肠炎 ,而对照组未见肉芽肿性肠炎和溃疡形成 .两组肉芽肿性肠炎的发病率有显著性差异 (P <0 0 5) .结果表明 :利用副结核杆菌接种地鼠 ,建立了一个模拟克隆病的肉芽肿性肠炎小动物模型 . 40 rats were randomly divided into two groups. In the experimental group, 20 Mycobacterium tuberculosis were inoculated intraperitoneally. In the control group, 20 rabbits were inoculated with saline and dead bacteria (10 in each) respectively. After 8 months, the animals were sacrificed Neutrophil enteritis and granulomatous enteritis were found in 80% (16/20) of the experimental group, but no granulomatous enteritis and ulcer were found in the control group.The incidence of granulomatous enteritis was significantly different between the two groups (P <0.05). The results showed that a murine model of granulomatous enteritis was established by inoculation of Mycobacterium tuberculosis.