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目的研究益气活血化痰方药对肺纤维化大鼠支气管肺泡灌洗液(BALF)中白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平及血液流变性变化的影响。方法用平阳霉素诱发大鼠的肺纤维化建立模型,观察空白组、模型组、中药1组(1.86 g/100 g)、中药2组(3.72 g/100 g)在第28天的指标变化情况。结果模型大鼠BALF中IL-8、TNF-α水平、全血黏度、血浆黏度及血小板聚集率均明显升高,红细胞变形能力显著下降(P<0.01或P<0.05);中药1、2组均可降低IL-8、TNF-α的致肺纤维化的趋化作用,降低全血黏度、血浆黏度及血小板聚集率水平,升高红细胞的变形能力(P<0.05),以中药2组作用明显。结论益气活血化痰方药对用平阳霉素诱发大鼠的肺纤维化病变有明显的防治作用。
Objective To study the effect of Yiqihuoxuehuayu prescription on the levels of interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α) and the changes of hemorheology in bronchoalveolar lavage fluid (BALF) in rats with pulmonary fibrosis Impact. Methods A rat model of pulmonary fibrosis induced by pingyangmycin was established. The changes of the indexes in the blank group, model group, traditional Chinese medicine group 1 (1.86 g/100 g), and traditional Chinese medicine 2 group (3.72 g/100 g) on the 28th day were observed. Happening. Results The levels of IL-8, TNF-α, whole blood viscosity, plasma viscosity and platelet aggregation rate in BALF of model rats were significantly increased, and the red blood cell deformability was significantly decreased (P<0.01 or P<0.05); Both can reduce the chemotaxis of pulmonary fibrosis induced by IL-8 and TNF-α, decrease the level of whole blood viscosity, plasma viscosity and platelet aggregation, and increase the deformability of red blood cells (P<0.05). obvious. Conclusion Yiqi Huoxue Huayu Recipe has significant preventive and therapeutic effects on lung fibrosis induced by Pingyangmycin in rats.