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目的了解贵州省水族人群β鄄地中海贫血的发病情况。方法采用“红细胞休克一管定量法”测定红细胞脆性,醋酸纤维素薄膜电泳分离测定,一分钟碱变性法测定HbF。结果在受检的1090人中,共检出β鄄地中海贫血携带者66例,检出率为6.06%,其中男性36例,女性30例,男女比例为1.2∶1。结论在贵州省三都地区水族人群中β鄄地中海贫血有较高的发生率,通过此次调查可使该人群对β鄄地中海贫血的严重危害性有所认识和引起有效的重视,这对开展优生优育,提高人口素质具有重要意义。
Objective To understand the incidence of β-thalassemia in aquatic population in Guizhou Province. Methods The erythrocyte fragility was determined by “one set of quantitative assay of erythrocytes”. HbF was determined by electrophoresis of cellulose acetate membrane and one minute alkali denaturation. Results Among the 1090 subjects examined, 66 cases of carriers of β-thalassemia were detected, the detection rate was 6.06%. There were 36 males and 30 females, the ratio of male to female was 1.2: 1. Conclusion The prevalence of β-thalassemia in aquatic population is relatively high in Sandu, Guizhou Province. Through this survey, the population may be aware of and seriously pay attention to the serious harm of β-thalassemia. Prenatal and postnatal care, improve the quality of the population is of great significance.