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目的观察缬沙坦对高血压病患者的降压疗效及对左室肥厚和舒张功能的影响。方法高血压伴左室肥厚患者52例,给予缬沙坦80mg,每日一次,总疗程3个月。超声心动图分别观察治疗前后心脏结构和舒张功能情况。结果高血压病患者治疗后收缩压、舒张压均下降;室间隔舒张末期厚度及左室后壁舒张末期厚度明显减轻。结论缬沙坦能有效逆转高血压患者左心室肥厚,改善左心室舒张功能。
Objective To observe the antihypertensive effect of valsartan in patients with essential hypertension and its effect on left ventricular hypertrophy and diastolic function. Methods Fifty-two hypertensive patients with left ventricular hypertrophy were given valsartan 80 mg once daily for 3 months. Echocardiography were observed before and after treatment of cardiac structure and diastolic function. Results After treatment, the systolic pressure and diastolic pressure of hypertensive patients decreased; the thickness of interventricular septum and end diastolic thickness of left ventricular wall were significantly reduced. Conclusion Valsartan can effectively reverse left ventricular hypertrophy in hypertensive patients and improve left ventricular diastolic function.