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目的研究HF患者NT-proBNP检测的临床意义。方法检测60例健康体检者(对照组)和382例HF患者(观察组)及80例HF患者治疗后第7天及第15天血清NT-proBNP水平。结果观察组血清NT-proBNP水平显著高于对照组,差异具有统计学有意义(P<0.01);观察组心功能分级不同血清NT-proBNP水平也具有明显差异,具有统计学有意义(P<0.01),并且随着心功能分级的不断升高,患者的血清中NT-proBNP水平浓度也呈现升高的趋势。80例HF治疗患者第7、15天采血检测结果显示:随着心功能持续改善,病人的NT-proBNP水平持续下降,前后差异具有统计学意义。(P<0.01)。结论血清NT-ProBNP水平检测对HF患者的诊断、病情评估和疗效评价有重要临床意义。
Objective To investigate the clinical significance of detecting NT-proBNP in HF patients. Methods Serum levels of NT-proBNP were detected on day 7 and day 15 in 60 healthy subjects (control group), 382 HF patients (observation group) and 80 HF patients. Results The level of serum NT-proBNP in the observation group was significantly higher than that in the control group (P <0.01). There was also a significant difference in NT-proBNP levels between the observation group and the control group (P < 0.01). And with the increasing of heart function classification, the serum NT-proBNP level in patients also showed an increasing trend. The results of blood tests on the 7th and 15th days in 80 HF patients showed that NT-proBNP level in patients continued to decrease with the continuous improvement of cardiac function, and the difference was statistically significant before and after treatment. (P <0.01). Conclusion The detection of serum NT-ProBNP level has important clinical significance in diagnosis, assessment of disease and evaluation of therapeutic effect in patients with HF.