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慢性乙型肝炎是当前严重危害世界人类健康的传染病。乙型肝炎病毒(HBV)感染后大多数发展为慢性肝炎,最终可能发展为肝硬化、肝细胞癌。目前常用的抗HBV药物主要有干扰素和核苷(酸)类似物,但疗效都不很理想,特异性差,易出现耐药性。RNA干扰(RNAinterference,RNAi)是一种普遍存在
Chronic hepatitis B is an infectious disease that is currently seriously endangering human health in the world. Hepatitis B virus (HBV) infection most of the development of chronic hepatitis, eventually may develop cirrhosis, hepatocellular carcinoma. The commonly used anti-HBV drugs are mainly interferon and nucleoside (acid) analogues, but the efficacy is not very good, poor specificity, prone to drug resistance. RNA interference (RNA interference) is a ubiquitous phenomenon