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Ｂ（ａ）Ｐ和ＣＴＰ是煤焦化作业人群中职业性肺癌发病率与死亡率增高的重要因素。本研究应用体外细胞转化模型，观察了微量元素硒（Ｓｅ）对Ｂ（ａ）Ｐ和ＣＴＰ诱发人胚肺细胞癌前变化的保护作用。结果表明，人胚肺细胞分别经终浓度Ｂ（ａ）Ｐ和ＣＴＰ为１．０μｇ／ｍｌ处理之前３０分钟经Ｓｅ终浓度为１．０×１０－５Ｍ／ｍｌ预先保护后，分别进行体外传代至第１２～１３代时，出现形态学转化特征，与Ｓｅ防护组比较，转化程度减轻，或不发生转化，染色体损伤减轻，其防护效率分别为６２．９±１３．７％和５８．０±１７．０％，提示Ｓｅ对Ｂ（ａ）Ｐ和ＣＴＰ具有较好的防癌效果。
B (a) P and CTP are important factors in the increase of occupational lung cancer morbidity and mortality in coal coking workers. In this study, the in vitro cell transformation model was used to observe the protective effect of trace element selenium (Se) on precancerous changes of human embryo lung cells induced by B (a) P and CTP. The results showed that human embryonic lung cells were pre-protected with final concentration of 1.0 × 10-5M / ml 30 min before the final concentration of B (a) P and CTP was 1.0 μg / ml, respectively. At the 12th to 13th generation, morphological transformation appeared, and compared with the Se protection group, the degree of transformation was reduced or no transformation occurred, and the chromosome damage was relieved. The protective efficiency was 62.9 ± 13.7% and 58.0 ± 17.0%, suggesting that Se has good anti-cancer effect on B (a) P and CTP.