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目的探讨长托宁与阿托品合用对救治急性重度有机磷中毒(SAOPP)的效果。方法回顾分析近5年来,两种药物用不同的方法救治急性重度有机磷中毒50例。结果长托宁(Ⅰ组)抢救成功率93%;长托宁联合阿托品联用(Ⅱ组)抢救成功率96.3%;阿托品(Ⅲ组)抢救成功率82%;3组比较有显著差异(P<0.05)。结论长托宁与阿托品联合救治急性重度有机磷中毒,效果明显优于单用长托宁或阿托品,二者联用是目前救治急性重度有机磷中毒最好方法。
Objective To investigate the effect of combination of penehyclidine and atropine on the treatment of acute severe organophosphorus poisoning (SAOPP). Methods Retrospective analysis of the past five years, the two drugs in different ways to treat 50 cases of acute severe organophosphate poisoning. Results The success rate of salvage was 93% in the group of penehyclidine hydrochloride (group Ⅰ), 96.3% in the combination of penehyclidine and atropine (group Ⅱ), and 82% in the atropine group (Ⅲ) (P <0.05). Conclusions The combination of penehyclidine and atropine in the treatment of acute severe organophosphorus poisoning is obviously superior to that of penehyclidine or atropine alone. The combination of penehyclidine and atropine is the best method to treat acute severe organophosphate poisoning.