自从1946年抗凝疗法应用于急性心肌梗塞后,历来存在着热烈的争论。许多研究由于设计不同、可靠性不等,产生了矛盾的结果,给予不同的解释。在过去十年中,两组大系列随机且具有对照的研究显示,急性心肌梗塞病人不论应用抗凝疗法与否,其病死率并无显著差别;其后,另二个回顾性研究却报告治疗组与未治组的病死率有很大的差别(治疗组为10.8％与8.3％,非治疗组为26.7％与27.3％)。最近一文根据两组随机 Ever since the anticoagulant therapy was applied to acute myocardial infarction in 1946, there has been a heated debate. Many studies have conflicting results due to different designs and varying degrees of reliability, giving different interpretations. In the past decade, two large series of randomized, controlled studies have shown no significant difference in mortality among patients with acute myocardial infarction, whether anticoagulant therapy is used or not; thereafter, two other retrospective studies report treatment There was a large difference in mortality between the group and the control group (10.8% and 8.3% in the treatment group and 26.7% and 27.3% in the non-treatment group). The most recent article is based on two randomized groups