论文部分内容阅读
在低硒低维生素Ｅ的克山病病区粮中添加硒（Ｓｅ）或／和维生素Ｅ（ＶＥ）饲养大鼠１０周；用手术结扎大鼠心脏左冠状动脉前降支以造成急性心肌急性缺血模型。结果表明，术后４８小时低Ｓｅ低ＶＥ组磷脂酶Ａ＿２活力、花生四烯酸、血栓素、白三烯水平增高，前列环素水平降低，血清ＣＫ、ＬＤＨ增高，同时伴有谷眺甘肽过氧化物酶、铜锌超氧化物歧化酶、过氧化氢酶活力降低，脂质过氧化物含量增多。补Ｓｅ或ＶＥ对纠正上述变化有相似而又不尽相同的效果，而以联合补充效果最佳。结果提示，膳食摄人适量Ｓｅ和ＶＥ可能影响花生四烯酸代谢及其产物水平，改善急性缺血应激条件下心肌功能和代谢状态，减轻心肌急性缺血性损伤。
Selenium (Se) and / or vitamin E (VE) were fed to the Keshan disease ward with low selenium and low vitamin E for 10 weeks. The anterior descending branch of the left coronary artery was ligated to cause acute myocardial infarction Ischemia model. The results showed that the activities of phospholipase A_2, arachidonic acid, thromboxane and leukotriene increased, the level of prostacyclin decreased, the serum CK and LDH increased at 48 hours after operation, Peroxidase, copper-zinc superoxide dismutase, catalase activity decreased, lipid peroxides increased. Complementing Se or VE has similar and different effects on correcting the above changes, but the combination effect is the best. The results suggest that adequate dietary intake of Se and VE may affect the metabolism of arachidonic acid and its product levels, improve myocardial function and metabolic status under acute ischemic stress and reduce myocardial ischemic injury.