【摘 要】
：
目的:为减少紫杉醇临床使用过程中的毒副作用,对紫杉醇原料进行包合制备微球(囊)。方法:采用单凝法以明胶作为包合囊材、以适当的材料作为阻滞剂对紫杉醇微球制备工艺进行初
【机 构】
：
江西江中制药厂质检科,江西省中医院研究所,江西医学院,
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目的:为减少紫杉醇临床使用过程中的毒副作用,对紫杉醇原料进行包合制备微球(囊)。方法:采用单凝法以明胶作为包合囊材、以适当的材料作为阻滞剂对紫杉醇微球制备工艺进行初步的研究,并对相关工艺进行初步的探讨。结果:完成了对紫杉醇微球制备的相关方法、条件的研究。结论:该方法形成(囊)球条件稳定、成本低,重复性好,可作为紫杉醇微球制备的一项新的工艺用于制剂。
OBJECTIVE: To reduce the toxic side effects of paclitaxel during its clinical use, paclitaxel raw materials were prepared and encapsulated to prepare microspheres. Methods: The gelatin was encapsulated by the single coagulation method. The preparation process of paclitaxel microspheres was studied with appropriate materials as a blocker. The related technologies were discussed preliminarily. Results: The preparation of paclitaxel microspheres related methods and conditions were studied. CONCLUSION: This method has the advantages of stable conditions, low cost and good reproducibility. It can be used as a new process for the preparation of paclitaxel microspheres.
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