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观察了65例原发性高血压病人LPO、SOD、Tc,TG、LDL、HDL、血尿酸水平及其相互关系以及降压药的影响,与正常对照组比较,结果为:病人血LPo、SOD、Tc、TG、LDL及尿酸均显著增高;LPO与SOD、Tc、TG、LDL及尿酸均呈显著正相关,而与HDL/Tc呈显著负相关。经硝苯啶和哌唑嗪治疗后,两服药组平均动脉压、LPO、Tc显著下降,硝苯啶组SOD显著下降。提示原发性高血压脂质代谢素乱和LPO、血脂及尿酸在其病理生理过程中有协同作用及硝苯啶可能存在新的降压机制。
The levels of LPO, SOD, Tc, TG, LDL, HDL and serum uric acid in 65 patients with essential hypertension were observed and their correlations were observed. Compared with the normal control group, the results showed that LPO, SOD , Tc, TG, LDL and uric acid were significantly increased. LPO was positively correlated with SOD, Tc, TG, LDL and uric acid, but negatively correlated with HDL / Tc. After treatment with nifedipine and prazosin, mean arterial pressure, LPO and Tc in the two groups were significantly decreased, while SOD in the nifedipine group was significantly decreased. It is suggested that lipid metabolism disorder of essential hypertension and LPO, blood lipid and uric acid have a synergistic effect in the pathophysiological process and nifedipine may have a new antihypertensive mechanism.