论文部分内容阅读
据报道,幽门弯曲菌与慢性胃炎和消化性溃疡有关,但这种细菌的致病特性还未了解清楚。幽门弯曲菌能降解胃的粘蛋白,并产生一种尚待证明对胃粘膜有害作用的细胞毒素。为了解此菌毒素的活性是否与胃十二指肠粘膜的溃疡性损伤有关,作者比较了自消化性溃疡与单纯慢性胃炎患者分离的弯曲菌产生细胞毒素的频次。检查了经胃十二指肠内窥镜观察,且没有接受可能抗幽门弯曲菌药物治疗的180例病人。每个病人的胃窦和溃疡边缘采检5份活组织,1份用伊红苏木精染色作组
Campylobacter pylori is reported to be associated with chronic gastritis and peptic ulcer disease, but the pathogenic nature of this bacterium has not been well understood. Campylobacter pylori can degrade gastric mucin and produce a cytotoxin that has yet to prove its detrimental effect on gastric mucosa. To understand whether this mycotoxin activity is associated with ulcerative lesions of gastroduodenal mucosa, we compared the frequency of cytotoxicity of Campylobacter species isolated from patients with peptic ulcer and chronic gastritis. 180 patients who underwent gastroduodenal endoscopy and who did not receive drugs that might be resistant to Campylobacter pylori were examined. Each patient’s gastric antrum and ulcers were examined by 5 biopsies and 1 by hematoxylin-eosin staining