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目的：观察新的二氢吡啶类钙通道阻滞剂２，６－二甲基－４－（３－硝基苯基）－１，４－二氢－３，５－吡啶二羧酸－３－甲酯－５－正戊酯（ＭＮ９２０２）对角叉菜胶引起的大鼠血栓形成的影响，探讨其抗血栓形成作用的血液流变学机制。方法：大鼠ｓｃ角叉菜胶５ｍｇ·ｋｇ－１复制血栓模型。给药后观察大鼠尾部血栓形成状况，进行血液流变学分析。结果：ＭＮ９２０２０．１、１、１０μｍｏｌ·ｋｇ－１能对抗角叉菜胶引起的大鼠血栓黑尾的形成（Ｐ＜０．０５，Ｐ＜０．０１），呈现出明显的剂量依赖关系（ｒ＝０．９９９５）；０．０１，０．１，１，１０μｍｏｌ·ｋｇ－１能降低ＲＢＣ聚集指数（Ｐ＜０．０５，Ｐ＜０．０１），增强ＲＢＣ变形性（Ｐ＜０．０５，Ｐ＜０．０１），但不改变ＲＢＣ电泳迁移率；大剂量的ＭＮ９２０２１，１０μｍｏｌ·ｋｇ－１能降低切变率为１５０·ｓ－１、５０·ｓ－１、１·ｓ－１时全血粘度。结论：ＭＮ９２０２具有对抗角叉菜胶引起的大鼠血栓形成作用。其作用可能与其改善血液流变性特征有关。
AIM: To observe the effects of 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydro-3,5-pyridinedicarboxylate - methyl-5-n-pentyl ester (MN9202) on carrageenan-induced rat thrombosis, to explore its anti-thrombotic effect of the hemorheology mechanism. Methods: Rat sc-carrageenan 5mg · kg-1 thrombosis model. The rat tail thrombosis state was observed after administration, and the hemorheology was analyzed. Results: MN92020.1,1,10 μmol · kg-1 could antagonize the formation of carrageenan-induced thrombus black tail (P <0.05, P <0.01) in a dose-dependent manner r = 0.9995). 0.01, 0.1, 1 and 10μmol · kg-1 could reduce RBC aggregation index (P <0.05, P <0.01) and enhance RBC deformability (P < 05, P <0.01), but it did not change the electrophoretic mobility of RBC. High doses of MN92021 and 10μmol · kg-1 could reduce the shear rate to 150 · s-1 and 50 · s-1,1 · s-1 Whole blood viscosity. Conclusion: MN9202 has the anti-thrombotic effect on rat induced by carrageenan. Its role may be related to its characteristics of improving the blood rheology.