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目的探讨血清血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)、超敏C-反应蛋白(hsCRP)检测在肝癌治疗效果评价中的意义。方法选取2015年2月至2017年1月滕州市中心人民医院收治的采用动脉插管化疗栓塞术(TACE)治疗原发性肝癌(HCC)患者200例,治疗前、治疗7 d后检测其血清中VEGF、MMP-9、hs-CRP水平,并比较治疗前与治疗7 d后、不同治疗效果(完全缓解72例、部分缓解81例、疾病稳定34例和疾病进展13例)和远期预后(随访2年,复发37例,未复发163例)患者间上述指标的差异。结果治疗7 d后,HCC患者血清中的VEGF、MMP-9、hs-CRP水平均明显低于治疗前,差异有统计学意义(P<0.05);随着患者治疗效果越显著,其血清中的VEGF、MMP-9、hs-CRP水平越降低,差异均有统计学意义(P<0.05);肝癌复发患者血清中的VEGF、MMP-9、hs-CRP水平均显著高于未复发患者,差异有统计学意义(P<0.05)。结论血清中VEGF、MMP-9、hs-CRP检测有助于肝癌治疗效果及远期预后判断。
Objective To investigate the significance of serum vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and hsCRP in the evaluation of the therapeutic effect of hepatocellular carcinoma. Methods Totally 200 patients with primary hepatic carcinoma (HCC) treated with arterial catheterization and chemoembolization (TACE) from February 2015 to January 2017 in Tengzhou Central People’s Hospital were enrolled. Before treatment and 7 days after treatment, serum The levels of VEGF, MMP-9 and hs-CRP were compared between the two groups. Before treatment and after 7 days of treatment, different treatment effects (complete remission 72, partial remission 81, stable disease 34 and disease progression 13) and long-term prognosis (Follow-up of 2 years, 37 cases of recurrence, 163 cases of non-recurrence) in patients with the above indicators differences. Results Serum levels of VEGF, MMP-9 and hs-CRP in HCC patients after 7 days of treatment were significantly lower than those before treatment (P <0.05). As the treatment effect was more significant, the serum levels of VEGF The levels of VEGF, MMP-9 and hs-CRP in patients with recurrent HCC were significantly higher than those in patients without recurrence, The difference was statistically significant (P <0.05). Conclusion The detection of VEGF, MMP-9 and hs-CRP in serum can be helpful to the therapeutic effect and long-term prognosis of hepatocellular carcinoma.