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目的分析研究前列地尔对冠心病合并糖尿病患者介入术后造影剂肾病的影响,为接受介入术治疗的冠心病合并糖尿病患者预防造影剂肾病提供新的思路。方法 100例经皮冠状动脉介入治疗的冠心病合并糖尿病患者,随机分为观察组与对照组,各50例。对照组采用常规治疗方式,观察组在常规治疗基础上采用前列地尔注射液治疗,对比两组患者术前及术后3 d时肾功能指标变化情况、炎症性指标变化情况、造影剂肾病发生情况。结果术前两组患者肾功能各项观察及炎症性指标对比差异无统计学意义(P>0.05),手术治疗后,观察组各项指标均优于对照组(P<0.05);观察组造影剂肾病发病率为4.0%远低于对照组的16.0%(P<0.05)。结论前列地尔注射液能够有效改善经皮冠状动脉介入治疗的冠心病合并糖尿病患者肾功能指标及炎症性指标,降低造影剂肾病发病率,具有一定临床价值,值得推广运用。
Objective To investigate the effect of alprostadil on contrast-induced nephropathy in patients with coronary heart disease complicated with diabetes mellitus and to provide new ideas for prevention of contrast-induced nephropathy in patients with coronary heart disease and diabetes mellitus treated by interventional therapy. Methods 100 patients with coronary artery disease and percutaneous coronary intervention with diabetes mellitus were randomly divided into observation group and control group, 50 cases each. The control group was treated by routine treatment. The observation group was treated with alprostadil injection on the basis of routine treatment. The changes of renal function indexes, inflammatory indexes and the contrast agent nephropathy were compared before and 3 days after operation Happening. Results There was no significant difference between the two groups in the observation of renal function and the inflammatory indexes (P> 0.05). After the operation, the indexes in the observation group were better than those in the control group (P <0.05) The incidence of nephropathy was 4.0% lower than that of the control group (16.0%, P <0.05). Conclusion Alprostadil injection can effectively improve renal function indexes and inflammatory indexes in patients with coronary heart disease and diabetes mellitus after percutaneous coronary intervention and reduce the incidence of contrast agent nephropathy, which is of clinical value and worthy of promotion and application.