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通过量化手段确定各种基本病理变化在肝病诊断中的价值 ,建立肝组织病理活动性量化诊断标准及坐标系。方法 选取基本病理变化各 11项分别作为诊断的急性和慢性指标 ,每项指标均赋于一定分值和级差 ,各单项分值叠加分别得出肝组织急性活动性指数和肝组织慢性活动性指数 ,以慢性分值为横坐标 ,急性分值为纵坐标建立坐标系。对 10 0 8例各类肝病进行评价并与常规读片及Knodell HAI对比观察。结果行方差分析及 q检验。 结果 急重肝、亚重肝、慢重肝的HAAI分值分别为 43 .5 6± 9.0 8,5 1.6 3± 12 .13和 6 5 .45± 17.5 1(P <0 .0 1) ;轻、中、重度慢性肝炎的HCAI分别为 13 .2 5± 6 .90 ,40 .2 9± 10 .99和 5 0 .0 2± 9.78(P <0 .0 1)。静止性肝硬变与活动性肝硬变的HAAI分别为 31.17± 9.0 7和 6 4.96± 16 .6 0 (P <0 .0 1)。随机抽取的 12 0例肝标本 ,诊断总符合率达 6 6 .6 6 %～ 10 0 %。结论 该标准应用方便 ,诊断准确 ,重复性强 ,具有良好的区别性。
Through quantitative means to determine the value of a variety of basic pathological changes in the diagnosis of liver disease, establish quantitative diagnostic criteria and coordinate system of liver pathological activity. Methods Eleven items of basic pathological changes were selected as acute and chronic indicators of diagnosis, each index was given a certain score and grade, the individual scores were superimposed to obtain the acute activity index of liver tissue and chronic activity index of liver tissue , The chronic score as abscissa, the acute score for the vertical coordinate establishment coordinate system. A total of 108 cases of various types of liver disease were evaluated and compared with routine readings and Knodell HAI. Results of variance analysis and q test. Results The HAAI scores of acute, severe and chronic severe hepatitis were 43.56 ± 9.0 8,5 1.6 3 ± 12.13 and 6.55 ± 17.51 (P <0.01), respectively. The HCAI of mild, moderate and severe chronic hepatitis were 13.25 ± 6.90, 40.29 ± 10.99 and 5.0 ± 9.78 (P <0.01), respectively. The HAAI values of resting cirrhosis and active cirrhosis were 31.17 ± 9.07 and 6 4.96 ± 16.60 (P <0.01), respectively. 120 randomly selected liver specimens, the diagnosis of the total compliance rate of 6.66% ~ 100%. Conclusion The standard is easy to use, accurate diagnosis, strong repeatability and good distinction.