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目的:研究慢性肝病血清层粘蛋白(LN)与白、球蛋白含量变化的关系。方法:对177例慢性肝病患者采用化学发光法测定血清LN含量,采用全自动生化分析仪AU5400检测血清白蛋白和球蛋白的含量。结果:慢性肝病患者血清LN含量显著高于正常人群(P<0.01),以LN大于等于130 ng/ml和小于130 ng/ml将患者分为两组,二者白蛋白和球蛋白含量比较差异高度显著。结论:血清LN变化与慢性肝病病情严重程度关系密切。
Objective: To study the relationship between serum laminin (LN) and white and globulin contents in chronic liver disease. Methods: Chemiluminescence was used to determine serum LN in 177 patients with chronic liver disease. Serum albumin and globulin were detected by AU5400 automatic biochemical analyzer. Results: The level of serum LN in patients with chronic liver disease was significantly higher than that in the normal population (P <0.01). The patients were divided into two groups with LN of 130 ng / ml and less than 130 ng / ml, the difference of albumin and globulin Highly significant. Conclusion: The change of serum LN is closely related to the severity of chronic liver disease.