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了解ＭＴＳ１／ｐ１６基因与胆道恶性肿瘤发生及生物学行为的关系。方法 采用免疫组化方法观察该基因产物ｐ１６蛋白在胆道恶性肿瘤的表达情况。结果ＭＴＳ１／ｐ１６在胆道恶性肿瘤中阳性表达率明显低于胆道良性病变（Ｐ＜０．０１），且与肿瘤的浸润及淋巴结转移密切相关（Ｐ＜０．０１），但与肿瘤的病理类型及分化程度无相关性（Ｐ＞０．０１）。结论检测ＭＴＳ１／Ｐ１６对临床正确估计胆道恶性肿瘤的浸润性、淋巴结转移潜能及判断预后有重要价值。
To understand the relationship between MTS1/p16 gene and biliary malignancy and biological behavior. Methods Immunohistochemistry was used to observe the expression of p16 protein in biliary malignant tumors. Results The positive expression rate of MTS1/p16 in biliary malignant tumors was significantly lower than that of biliary benign lesions (P<0.01), and was closely related to tumor invasion and lymph node metastasis (P<0.01), but the pathological type of tumor was similar to that of tumors. There was no correlation with the degree of differentiation (P>0.01). Conclusion The detection of MTS1/P16 has important clinical value in the correct estimation of invasiveness, lymph node metastasis and prognosis of biliary malignant tumors.