目的建立毛细管气相色谱法测定普拉格雷中的有机溶剂残留量。方法用DB624毛细管气相色谱柱,FID检测器,以丙酮为内标进行测定。结果乙醇、乙醚、二氯甲烷、乙酸乙酯的线性范围分别为50～800(r=0.999 5)、50～800(r=0.999 1)、6～96(r=0.999 4)、50～800 mg.L-1(r=0.999 6);乙醇、乙醚、二氯甲烷、乙酸乙酯的平均回收率分别为99.51%、98.97%、99.25%、99.32%;RSD为1.25%、1.14%、1.23%、1.05%(n=9)。结论本方法适用于普拉格雷中的有机溶剂残留量的测定。 Objective To establish a capillary gas chromatographic method for the determination of residual organic solvents in prasugrel. Methods DB624 capillary gas chromatography column, FID detector, with acetone as the internal standard determination. Results The linear range of ethanol, ether, dichloromethane and ethyl acetate was 50 ~ 800 (r = 0.999 5), 50 ~ 800 (r = 0.999 1), 6 ~ 96 The average recoveries of ethanol, ethyl ether, methylene chloride and ethyl acetate were 99.51%, 98.97%, 99.25% and 99.32%, respectively. The RSDs were 1.25%, 1.14% and 1.23 %, 1.05% (n = 9). Conclusion This method is suitable for the determination of organic solvent residues in prasugrel.