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目的探索HCV基因型在南京与广东地区的分布以及与丙型肝炎(丙肝)感染途径的相关性。方法采用HCV基因分型测序法进行基因分型检测。结果南京地区与广东地区丙肝感染者基因型均以1b为主,2a型次之,分别为75.16%、62.90%和14.38%、27.42%;亦发现有混合基因型。南京地区基因2a型比例与广东地区基因2a型比例比较,差异有统计学意义(P<0.05)。结论南京与广东地区丙肝感染者基因型均以1b、2a型为主,广东地区基因2a型分布明显高于南京地区。
Objective To explore the distribution of HCV genotypes in Nanjing and Guangdong and their relationship with hepatitis C (HCV) infection. Methods HCV genotyping and sequencing were used to detect genotypes. Results The genotypes of hepatitis C virus infection in Nanjing and Guangdong were 1b, followed by 2a followed by 75.16%, 62.90% and 14.38% and 27.42% respectively. A mixed genotype was also found. The proportion of gene type 2a in Nanjing was significantly higher than that of genotype 2a in Guangdong (P <0.05). Conclusions Genotypes 1b and 2a are predominant in patients with hepatitis C infection in Nanjing and Guangdong Provinces. Genotype 2a distribution in Guangdong is significantly higher than that in Nanjing.