脊柱关节病(spondyloarthritis,SpA)是血清阴性脊柱关节病的简称,指血清类风湿因子阴性,脊柱关节受累的一组互有关联的多系统炎症性疾病。这组疾病包括强直性脊柱炎、瑞特综合征、牛皮癣关节炎以及肠病性关节病等。这几种疾病在临床上有许多的共同特征:(1)血清类风湿因子阴性,实际上阳性率同一般正常人群;(2)有家族聚集倾向;(3)与HLA-B27抗原有不同程度的关联,其中以强直性脊柱炎和瑞特综合征尤为密切;(4)皆可影响脊柱,都有不同程度的骶髂关节炎,也可影响 Spondyloarthritis (SpA) is short for seronegative spondyloarthropathies and refers to a group of inter-related multisystem inflammatory diseases with negative serum rheumatoid factor and spinal joints involvement. This group of diseases include ankylosing spondylitis, Reiter’s syndrome, psoriatic arthritis and enteropathy. These diseases have many clinical features in common: (1) serum rheumatoid factor negative, in fact, the positive rate with the general normal population; (2) there is a tendency of familial aggregation; (3) with HLA-B27 antigen to varying degrees Of which ankylosing spondylitis and Reiter syndrome are particularly close; (4) can affect the spine, have varying degrees of sacroiliac arthritis can also affect