论文部分内容阅读
目的探讨原发性宫颈小细胞癌的临床病理特征和免疫表型。方法对6例宫颈小细胞癌进行组织病理学观察和免疫组化检测,并复习所有临床资料。结果6例子宫颈小细胞癌患者中单纯小细胞癌4例,伴腺样分化1例,伴腺鳞癌及宫内膜腺鳞癌1例。临床表现为阴道不规则出血伴宫颈肿物。组织学上肿瘤主要由大小一致的小卵圆形细胞组成。免疫组化:5例肿瘤细胞CK和Syn(+),4例CgA和CD99(+),1例5-HT(+),3例HPV(+)。随访4例死亡。结论宫颈小细胞癌是一种罕见的高度恶性肿瘤,其发生可能与HPV感染有关,CK、CgA和Syn是宫颈小细胞癌较为特异的免疫标记物。
Objective To investigate the clinicopathological characteristics and immunophenotype of primary small cell carcinoma of the cervix. Methods Six cases of cervical SCC were observed by histopathology and immunohistochemistry, and all the clinical data were reviewed. Results Of the 6 patients with small cell carcinoma of the cervix, 4 were simple small cell carcinoma, 1 with adenoid differentiation, 1 with adenosquamous carcinoma and endometrial adenosquamous carcinoma. Clinical manifestations of irregular vaginal bleeding with cervical mass. Histologically, tumors consist mainly of oval cells of uniform size. Immunohistochemistry: 5 cases of CK and Syn (+), 4 cases of CgA and CD99 (+), 1 case of 5-HT (+), 3 cases of HPV (+). Four patients were followed up. Conclusion Small cell carcinoma of the cervix is a rare and highly malignant tumor which may be related to HPV infection. CK, CgA and Syn are more specific immunological markers of small cell carcinoma of the cervix.