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目的探讨血清胱抑素C(CysC)在慢性肾脏病(CKD)患者肾功能评估中的临床价值,为临床应用提供更多的理论依据。方法以2011年12月至2012年12月肾内科住院治疗的80例CKD患者为观察对象,测定CysC、血肌酐(SCr)、血尿素氮(BUN)及血白蛋白(ALB),以MDRD公式计算所得肾小球滤过率(GFR)为诊断标准,评价CysC在CKD早期诊断中的意义。结果 CysC在各组间差异均有统计学意义(P<0.05),相关分析CysC与SCr、BUN呈正相关,与GFR呈负相关,且相关系数最高。结论 CysC可作为评价早期慢性肾脏病患者的敏感指标,与SCr、BUN相比能更早、更客观地反映肾小球滤过功能。
Objective To investigate the clinical value of serum cystatin C (CysC) in the assessment of renal function in patients with chronic kidney disease (CKD) and provide more theoretical basis for clinical application. Methods Eighty CKD patients hospitalized in Department of Nephrology from December 2011 to December 2012 were enrolled in this study. CysC, serum creatinine (SCr), blood urea nitrogen (BUN) and serum albumin (ALB) Calculated glomerular filtration rate (GFR) as the diagnostic criteria to evaluate the significance of CysC in the early diagnosis of CKD. Results There were significant differences in CysC between groups (P <0.05). Correlation analysis showed that CysC was positively correlated with SCr and BUN, negatively correlated with GFR, and had the highest correlation coefficient. Conclusion CysC can be used as a sensitive index to evaluate patients with early CKD, and reflect glomerular filtration function earlier and more objectively than SCr and BUN.