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目的研究长方案促排卵患者注射人绒毛膜促性腺激素(Human chorionic gonadotropin,HCG)日血清雌二醇(Estradiol,E2)/孕酮(Progesterone,P)比值(E2/P)对体外受精-胚胎移植(in vitrofertilization and embryo transfer,IVF-ET)结局的影响。方法回顾性分析2010年413个IVF-ET周期的资料,将E2/P值分为3组,Ⅰ组:E2/P≤1.2,Ⅱ组:1.25.0,对3组的相关数据进行分析。结果 3组获卵数、2PN受精率均存在差异,有统计学意义(P<0.05)。卵巢过度刺激综合征发生率Ⅲ组高于Ⅰ、Ⅱ组,Ⅲ组与Ⅱ组之间比较有统计学意义(P<0.05)。种植率及妊娠率Ⅱ组最高而流产率最低,流产率Ⅱ组低于Ⅲ组,有统计学意义(P<0.05);种植率、妊娠率Ⅰ组均低于Ⅱ、Ⅲ组,有统计学意义(P<0.05)。结论合适的E2/P值有利于获得较高的妊娠率、更低的流产率和卵巢过度刺激综合征发生率,并使IVF-ET的结局更好。
Objective To study the effects of estradiol (E2) / progesterone (P) ratio (E2 / P) on human fertilization - embryo transfer in long-term ovulation induction patients with human chorionic gonadotropin (HCG) Implantation in Vitrofertilization and Embryo Transfer (IVF-ET) Outcomes. Methods The data of 413 cycles of IVF-ET in 2010 were retrospectively analyzed. The E2 / P values were divided into three groups: group Ⅰ: E2 / P≤1.2; group Ⅱ: 1.2 5.0, the relevant data of 3 groups are analyzed. Results The numbers of oocytes and 2PN fertilization in 3 groups were significantly different (P <0.05). The incidence of ovarian hyperstimulation syndrome in group Ⅲ was higher than that in group Ⅰ and Ⅱ, and there was a significant difference between group Ⅲ and Ⅱ (P <0.05). The implantation rate and pregnancy rate were the highest in group Ⅱ and the lowest in abortion group. The rate of miscarriage in group Ⅱ was lower than that in group Ⅲ (P <0.05). The implantation rate and pregnancy rate in group Ⅰ were lower than those in groups Ⅱ and Ⅲ Significance (P <0.05). Conclusions The appropriate E2 / P value is beneficial to obtain higher pregnancy rate, lower abortion rate and ovarian hyperstimulation syndrome incidence and make the outcome of IVF-ET better.