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采用羊水肌酸激酶(CK)、乳酸脱氢酶(LDH)、肌红蛋白(Mb)联合测定进行12例DMD产前诊断与产后复查,部分病例经PCR检测对照研究。证实羊水CK的诊断符合率为83.3%(10/12);LDH为58.3%(7/12);Mb为90%(10/11)。三者联合检测综合判定产前诊断符合率达95%以上。
Twelve DMD prenatal and postnatal follow-up tests were performed using amniotic fluid creatine kinase (CK), lactate dehydrogenase (LDH), and myoglobin (Mb). Some cases were compared by PCR. Confirmation of amniotic fluid CK diagnostic accuracy was 83.3% (10/12); LDH was 58.3% (7/12); Mb was 90% (10/11). Comprehensive detection of the three combined prenatal diagnosis consistent rate of 95% or more.