从首个淋巴管内皮(lymphatic endothelium,LE)标记物VEGFR-3被发现开始,人们就没有停止对新的淋巴管内皮标志物的寻找。近些年来,已经发现了多种淋巴管内皮标记物。LE标记物为观测肿瘤淋巴管开辟了新的道路。在对LE标记物的研究过程中,其对肿瘤淋巴管的变化是否能起到特异性的反应,更引起了人们的关注。肿瘤的淋巴道转移是肿瘤细胞扩散的重要渠道,在转移过程中肿瘤内部的淋巴管是否发生了变化,这种变 From the beginning of the discovery that the first lymphatic endothelium (LE) marker VEGFR-3 was found, one did not stop looking for new lymphatic endothelial markers. In recent years, a variety of lymphatic endothelial markers have been discovered. LE markers open up a new path for the observation of tumor lymphatics. In the process of LE marker research, whether it can play a specific response to tumor lymphatic changes has aroused people’s attention. Lymphatic metastasis of tumor is an important channel for the proliferation of tumor cells. Whether the lymphatic vessels in the tumor have changed during the metastasis changes will change