论文部分内容阅读
目的研究血小板活化对肺癌患者病情和预后的影响。方法采用放射免疫法和酶联免疫法测定168例肺癌和80例正常人血浆血栓烷B2(TXB2)、11-去氢-血栓烷B2(DH-TXB2、凝血酶敏感蛋白(TSP)、β-血小板球蛋白(β-TG)、血小板α-颗粒膜蛋白(GMP-140)、血清纤维结合蛋白(FN)含量。结果①与对照组比较:腺癌、小细胞癌TXB2、DH-TXB2、TSP、β-TG、GMP-140均升高,FN均降低;鳞癌TXB2、DH-TXB2、TSP、GMP-140、CGMP升高,FN降低。②与小细胞癌比较:腺癌DH-TXB2、TSP降低;鳞癌GMP-140降低,FN升高。③与各自对照组比较:晚期组、TXB2、DH-TXB2、TSP、β-TG、GMP-140升高,FN降低;远处转移组TXB2、DH-TXB2、TSP、β-TG升高,FN降低;手术后组DHTXB2、TSP、β-TG、GMP-140降低,FN升高,合并感染组TSP升高,FN降低;二周内死亡组TXB2,DH-TXB2,TSP,β-TG,GMP-140升高,FN降低。结论①肺癌患者血小板广泛激活。晚期,远处转移,二周内死亡病例激活较重。②早、中期病例手术后血小板活化减轻。
Objective To study the influence of platelet activation on the condition and prognosis of patients with lung cancer. Methods The radioimmunoassay and enzyme-linked immunosorbent assay were used to determine the plasma levels of TXB2, DH-TXB2, TSP, Β-TG, GMP-140 and FN were detected.Results①Compared with control group, adenocarcinoma, small cell carcinoma TXB2, DH-TXB2, TSP TXB2, TSP, GMP-140, CGMP increased, FN decreased.②Compared with small cell carcinoma, the expression of DH-TXB2, TSP, GMP-140 and FN in squamous cell carcinoma.③Compared with the control group, the levels of TXB2, DH-TXB2, TSP, β-TG and GMP-140 increased and the FN decreased in the distant metastasis group The levels of DHTXB2, TSP, β-TG and GMP-140 decreased and FN increased after operation. TSP increased and FN decreased in the infected group. The death in two weeks TXB2, TXB2, TSP, β-TG, GMP-140 were increased and FN was decreased.Conclusion ① Platelets are widely activated in patients with lung cancer, late and distant metastasis, severe death in two weeks.②The early and middle stage cases Platelet activation is relieved after surgery.