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目的探讨血浆心钠素在阻塞性黄疸患者并发急性肾功能衰竭中的作用和意义。方法检测了２３例阻塞性黄疸患者术前及术后第２、５、１０、１５ｄ血浆心钠素水平，同时观察其肾功能变化。结果术前血浆心钠素水平黄疸组较对照组明显增高，内生肌酐清除率明显降低。术后内生肌酐清除率随血浆心钠素下降而呈上升趋势。１０ｄ恢复正常。结论阻塞性黄疸患者血浆心钠素水平升高可能是其并发肾功能受损的一个重要原因。
Objective To investigate the role and significance of plasma atrial natriuretic peptide in patients with obstructive jaundice complicated by acute renal failure. Methods Twenty-three patients with obstructive jaundice were tested for plasma atrial natriuretic peptide before and after operation on the 2nd, 5th, 10th and 15th days. The changes of renal function were also observed. Results Preoperative plasma atrial natriuretic peptide levels in patients with jaundice were significantly higher than those in the control group, and endogenous creatinine clearance rate was significantly lower. Postoperative creatinine clearance rate with the decline in plasma atrial natriuretic and upward trend. 10d returned to normal. Conclusions The increase of plasma atrial natriuretic peptide in patients with obstructive jaundice may be an important reason for its impaired renal function.