报道了尼美舒利人体血药浓度的 RP- HPL C测定法。采用 Hypersil BDS C1 8不锈钢色谱柱 ,血浆样品经乙酸乙酯抽提处理后测定。方法线性范围 0 .2 0～ 2 5 mg/ L(r=0 .9999) ,平均回收率为 92 .3%～ 99.4% ,最低检测浓度为6 0μg/ L The RP-HPL C assay for nimesulide human blood concentration was reported. Using Hypersil BDS C1 8 stainless steel column, plasma samples were determined by ethyl acetate extraction. The linear range of the method was 0.2-2.5 mg / L (r = 0.9999). The average recovery was 92.3% ~ 99.4%. The lowest detection concentration was 60μg / L