论文部分内容阅读
Introduction. Chronic inflammatory demyelinating polyrad-iculoneuropathy (CIDP) rarely develops in patients with solid organ transplantation. Patients and method. We describe the clinical, biological, electrophysiological and neuropathological features of 4 patients with solid organ transplantation who developed CIDP. Two patients had liver transplantation, one had kidney transplantation and one had lung transplantation. Results. All 4 patients developed in the months following transplantation a syndrome that fulfilled criteria for definite CIDP. All patients had immunosuppressive therapy, with ciclosporin + prednisolone in 2 cases, tacrolimus in 1 case and azathioprine + prednisolone + ciclosporin in one case. One patient had chronic HCV and HBV infection. Treatment with intravenous immune globulin (IVIG) and/or a change in immunosuppressive therapy improved the neuropathy in all cases. Conclusion. CIDP is a rare and potentially treatable condition that should be considered in all patients with solid organ transplantation who develop a rapidly disabling sensorimotor polyneuropathy. u001a
Introduction of Chronic inflammatory demyelinating polyrad-iculoneuropathy (CIDP) rarely develops in patients with solid organ transplantation. Patients and method. We describe the clinical, biological, electrophysiological and neuropathological features of 4 patients with solid organ transplantation who developed CIDP. Two patients had liver transplantation, one had kidney transplantation and one had lung transplantation. Results. All 4 patients developed in the following years transplantation a syndrome that fulfilled criteria for definite CIDP. All patients had immunosuppressive therapy, with ciclosporin + prednisolone in 2 cases, tacrolimus in 1 case and azathioprine + prednisolone + ciclosporin in one case. One patient had chronic HCV and HBV infection. Treatment with intravenous immune globulin (IVIG) and / or a change in immunosuppressive therapy improved the neuropathy in all cases. Conclusion. CIDP is a rare and potentially harmful treatable condition that should be considered in all pat ients with solid government transplantation who develop a rapidly disabling sensorimotor polyneuropathy. u001a