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目的观察早期使用呋塞米在足月新生儿重度窒息复苏后治疗中的效果。方法将我院2006年1月至2010年1月出生及治疗的98例重度窒息复苏后的足月新生儿,分为治疗组50例、对照组48例。治疗组在常规治疗基础上早期给予呋塞米治疗;对照组仅给予常规治疗,出现颅内高压症状时才给予降低颅内压治疗。结果治疗组在治疗过程中临床表现为缺氧缺血性脑病(HIE)的发生率48.0%,头颅CT分度为中、重度缺氧缺血性脑病的发生率8.0%;而对照组则分别为68.8%和22.9%,两组比较差异有统计学意义(P<0.05)。结论早期使用呋塞米治疗重度窒息复苏后的足月新生儿,可预防和减少新生儿缺氧缺血性脑病的发生,值得临床进一步推广和应用。
Objective To observe the effect of early use of furosemide in the treatment of severe neonatal asphyxia after full-term recovery. Methods A total of 98 full-term newborns who were born and treated in our hospital from January 2006 to January 2010 were divided into treatment group (n = 50) and control group (n = 48). The treatment group was treated with furosemide on the basis of conventional treatment. The control group was given conventional treatment only, and intracranial pressure was given only when symptoms of intracranial hypertension occurred. Results The clinical manifestations of the treatment group were Hypoxic-ischemic encephalopathy (HIE) incidence of 48.0%, head CT classification of moderate and severe hypoxic-ischemic encephalopathy incidence of 8.0%; while the control group were respectively 68.8% and 22.9%, respectively, with significant difference between the two groups (P <0.05). Conclusion The early use of furosemide in severe neonatal asphyxia after full-term neonatal resuscitation can prevent and reduce the incidence of neonatal hypoxic-ischemic encephalopathy, deserving further clinical application and application.