论文部分内容阅读
目的探讨影响狼疮肾炎(LN)高血压发生的相关因素。方法对729例LN患者完整临床病理资料进行回顾性分析,比较LN并发高血压组与LN不伴高血压组患者临床表现、实验室检查和病理学改变等方面的差别,利用单因素及多因素分析探讨LN并发高血压的危险因素。结果本组高血压发生率为34.3%,高血压发生率随着患者年龄增加、病程延长和肾功能恶化而逐渐增加,组间差异存在统计学意义;单因素分析提示男性,年龄≥45岁,病程≥3年,高血压家族史,尿蛋白≥2.0g/d,血肌酐≥133μmol/L,高胆固醇血症,肾小管间质指数≥5,新月体指数≥2,肾小球硬化指数≥2等是LN患者并发高血压的危险因素;多因素Logistic回归分析结果显示性别、年龄、血肌酐水平、肾小球硬化程度是LN高血压发生的独立影响因素。结论高血压是LN常见并发症,发生率高,其发生与家族史、性别、病程长短、蛋白尿程度、血肌酐水平等因素有关,应及时有效地控制血压水平。
Objective To investigate the related factors affecting the occurrence of lupus nephritis (LN). Methods The complete clinical and pathological data of 729 patients with LN were retrospectively analyzed. The differences of clinical manifestations, laboratory tests and pathological changes between patients with LN complicated with hypertension and those with LN without hypertension were compared. Single and multiple factors To analyze the risk factors of LN complicated with hypertension. Results The incidence of hypertension in this group was 34.3%. The incidence of hypertension increased with age, duration of disease and renal dysfunction. There was significant difference between groups. Univariate analysis showed that male, age ≥45 years, Duration of ≥ 3 years, family history of hypertension, urinary protein ≥ 2.0g / d, serum creatinine ≥ 133μmol / L, hypercholesterolemia, tubulointerstitial index ≥ 5, crescent index ≥ 2, glomerular sclerosis index ≥2 is a risk factor for hypertension in patients with LN. Multivariate Logistic regression analysis showed that gender, age, serum creatinine and glomerular sclerosis were independent risk factors for the occurrence of LN. Conclusions Hypertension is a common complication of LN with high incidence. The incidence of Hypertension is related to family history, gender, duration of disease, proteinuria, serum creatinine level and other factors. It is necessary to control the blood pressure level promptly and effectively.