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目的分析柳州市妇幼保健院儿童药物不良反应(ADR)的特点和规律。方法对柳州市妇幼保健院2011-2015年发生的265例ADR报告进行回顾性分析,并对目前儿童合理用药提出建议。结果 265例ADR报告中,引发不良反应的主要给药途径为静脉滴注(78.49%);引发不良反应的药物以抗感染类所占比例居首位(44.91%%);发生药物不良反应的年龄段为1~3岁(38.67%);不良反应累及器官或系统以皮肤及其附件系统所占比例最高(60.94%)。结论医院有必要推进开展临床儿童用药监测活动,临床工作中重视ADR,强调合理用药,以进一步降低ADR发生率,确保用药安全。
Objective To analyze the characteristics and laws of children’s adverse drug reaction (ADR) in Liuzhou MCH hospital. Methods A retrospective analysis of 265 cases of ADR in Liuzhou MCH from 2011 to 2015 was made, and some suggestions were put forward for rational use of drugs in children. Results Among the 265 ADR cases, the main route of adverse drug reaction was intravenous drip (78.49%). The proportion of adverse drug reactions in anti-infectives was the highest (44.91%). Adverse drug reactions The age range of 1 to 3 years old (38.67%); adverse reactions involving the organ or system with the highest proportion of the skin and its attachment system (60.94%). Conclusion It is necessary for the hospital to promote the monitoring of drug use in clinical children. ADR should be emphasized in clinical practice and rational use of drugs should be emphasized to further reduce the incidence of ADR and ensure the safety of medication.