ERα,ERβ在人体多种组织都有表达,包括乳房。但两者的组织学分布及相对表达水平有所不同。在正常乳腺组织的生长发育及大多数ER阳性乳腺癌的发生发展中,雌激素具有重要作用,该作用由ER所介导。随着ERβ的发现,关于ERα、ERβ与乳腺癌的研究已取得一定认识,并将渐趋深入。 ERα and ERβ are expressed in many tissues of the human body, including the breast. However, their histological distribution and relative expression levels are different. In the development of normal breast tissue and the development of most ER-positive breast cancers, estrogen plays an important role, which is mediated by ER. With the discovery of ERβ, studies on ERα, ERβ, and breast cancer have gained some understanding and will gradually deepen.