论文部分内容阅读
目的:观察健脾丸联合杞枣甘草汤、葡萄糖酸钙锌治疗儿童铅中毒的临床效果。方法:选取2014年6月至2016年5月我院收治的儿童铅中毒患儿30例为研究对象,采用随机数表法分为观察组和对照组各15例,对照组给予杞枣甘草汤、葡萄糖酸钙锌等药物治疗,观察组在此基础上加服健脾丸,均治疗2个月,对比两组治疗有效率,记录两组治疗前后主要症候积分及血铅(BPb)、血钙(BCa)、血锌(Zn)、血色素(Hb)等生化指标,同时观察肝肾功能[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、血尿素氮(BUN)、血肌酐(SCr)、血尿酸(UA)]变化,记录不良反应。结果:观察组治疗有效率93.33%高于对照组60.00%(P<0.05);治疗后观察组厌食、腹胀腹痛、夜寐不安、多动、注意力不集中等症候积分及总积分明显低于对照组(P<0.05);治疗后观察组BPb(79.38±2.54)μh/L低于对照组,而其BCa(107.76±2.98)mg/L、BZn(1.34±0.12)mg/L、Hb(110.23±1.84)g/L较对照组明显升高(P<0.05);观察组治疗后ALT、AST、ALP及BUN、SCr、UA均低于对照组(P均<0.05);治疗期间均未见明显不良反应。结论:健脾丸联合杞枣甘草汤、葡萄糖酸钙锌可有效治疗儿童铅中毒,改善患儿症状、生化指标及肝肾功能,且不良反应轻,值得在临床推广应用。
Objective: To observe the clinical effects of Jianpi pill combined with Qi jujube licorice soup and calcium gluconate on children lead poisoning. Methods: Thirty children with childhood lead poisoning admitted to our hospital from June 2014 to May 2016 were selected as the research object. The random number table was used to divide the observation group and the control group into 15 cases each. The control group was given Qi jujube licorice soup , Calcium zinc gluconate and other drugs. The observation group was given Jianpiliao pills on the basis of this treatment for 2 months. The treatment efficiency was compared between the two groups. The main symptom scores and blood lead (BPb) and blood BCA, Zn, Hb and other biochemical markers were observed. Liver and kidney function were also observed (ALT, AST, alkaline phosphatase (ALP), blood urea nitrogen (BUN), serum creatinine (SCr), blood uric acid (UA)] changes recorded adverse reactions. Results: The effective rate of treatment in observation group was 93.33% higher than that in control group (60.00%) (P <0.05). After treatment, the symptom scores and total scores of anorexia such as anorexia, abdominal distension and abdominal pain, sleepless nights, hyperactivity and inattention were significantly lower than those in control group (79.38 ± 2.54) μh / L in the observation group were lower than those in the control group (P <0.05). The BCb (107.76 ± 2.98) mg / L and the BZn (1.34 ± 0.12) mg / 110.23 ± 1.84) g / L was significantly higher than that of the control group (P <0.05). ALT, AST, ALP, BUN, SCr and UA in the observation group were lower than those in the control group (all P <0.05) See obvious adverse reactions. Conclusion: Jianpi pill combined with Qizao Gancao Decoction and calcium gluconate can effectively treat children lead poisoning, improve children’s symptoms, biochemical indexes and liver and kidney function, and the adverse reactions are light. It is worth to be popularized in clinic.