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研究了两种诱导分化剂星状孢子素（ｓｔａｕｒｏｓｐｏｒｉｎｅ）及金雀异黄素（ｇｅｎｉｓｔｅｉｎ）在诱导人早幼粒白血病细胞（ＨＬ－６０细胞）的过程中酪氨酸蛋白激酶（ＴＰＫ）及酪氨酸蛋白磷酸酶（ＰＴＰＰ）的活力变化。结果表明，两种分化诱导剂对胞浆及膜两部分的ＴＰＫ活力均有不同程度的抑制，而对这两部分的ＰＴＰＰ活力则有不同程度的激活作用，说明分化诱导剂可使ＨＬ－６０细胞内的酪氨酸的磷酸化水平提高，揭示了诱导分化与酪氨酸磷酸化及脱磷酸化之间的关系，为寻找新的抗癌药物提供了帮助。
The effects of two induced differentiation agents, staurosporine and genistein, on tyrosine protein kinase (TPK) and tyrosinase during induction of human promyelocytic leukemia cells (HL-60 cells) Changes in the activity of the protein tyrosine phosphatase (PTPP). The results showed that the two kinds of differentiation inducing agents inhibited the TPK activity in both cytoplasm and membrane in varying degrees, but had different degrees of activation on the two parts of PTPP activity, indicating that the differentiation inducing agent can make HL-60 Increased intracellular tyrosine phosphorylation, revealed the relationship between induced differentiation and tyrosine phosphorylation and dephosphorylation, in search of a new anticancer drug has provided help.