转移是恶性肿瘤的主要特征 ,又是恶性肿瘤治疗失败和患者死亡的主要原因。随着分子生物学的深入研究 ,人们对肿瘤的发生基础有了明确的认识。目前已知 ,肿瘤转移与肿瘤发生一样 ,不仅有促进基因的激活 ,还有抑制基因的失活。肿瘤转移抑制基因的存在是在细胞融合实验中证实的。 Metastasis is the main feature of malignant tumors, but also the main reason for the failure of treatment of malignant tumors and the death of patients. With the in-depth study of molecular biology, people have a clear understanding of the basis of the tumor. It is now known that tumor metastasis, like tumorigenesis, not only promotes gene activation but also inhibits gene inactivation. The presence of tumor metastasis suppressor genes was confirmed in cell fusion experiments.