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目的 探讨人工肝支持系统对重症肝炎的疗效。方法 应用日产ＫＭ —８８００ 血液净化仪对４３ 例重症病毒性肝炎选用不同的方法（ 血浆交换、血液灌流、血浆吸附等） 进行１０２ 次治疗，与对照组４４ 例比较。结果 明显急性、亚急性重症肝炎治愈好转率（６５ ．２２ ％ ） 明显高于对照组（２０ ．８３ ％ ） ；慢性重症肝炎治疗组治愈好转率（５５ ．００ ％ ） ；治疗组高于对照组（１５ ．００ ％ ） ；两组有显著性差异（ Ｐ＜ ０ ．０１） ；治疗组每次治疗后患者乏力、纳差、腹胀等症状明显改善，精神好转，肝功能血胆红素、ＡＳＴ 等明显降低（ Ｐ＜ ０ ．００１） ；血白蛋白升高（ Ｐ＜ ０ ．０１） ，球蛋白明显降低（ Ｐ＜０ ．００１） ，白球比例由倒置转为正常或接近正常范围。血ＢＵＮ、Ｃｒ、ＮＨ３ 等治疗后均有明显降低（ 分别为（ Ｐ＜ ０ ．００１ ，Ｐ＜ ０ ．０５ａｎｄ Ｐ＜ ０ ．００１） ，电解质治疗前后无显著性差异，均为正常范围。结论 ＡＬＳＳ 不失为目前治疗重症肝炎有效、安全的治疗手段，能显著地降低病死率，提高成活率。
Objective To investigate the effect of artificial liver support system on severe hepatitis. Methods 43 cases of severe viral hepatitis were treated with Nissan KM-8800 blood purification instrument for 102 times by different methods (plasma exchange, blood perfusion, plasma adsorption, etc.) compared with 44 cases in control group. The results showed that the improvement rate of acute and subacute severe hepatitis was significantly higher (65.22%) than that of the control group (20.83%); the treatment rate of chronic severe hepatitis (55.00%) was improved; the treatment group was higher than the control group (15.00%). There was significant difference between the two groups (P <0.01). After treatment, the symptoms such as fatigue, anorexia, abdominal distension and so on in the treatment group improved obviously, (P <0.01). The albumin was increased (P <0.01), the globulin was significantly decreased (P <0 .001), and the percentage of white sphere changed from inverted to normal or close to normal range. Blood BUN, Cr and NH3 were significantly decreased after treatment (P <0.001, P <0.05and P <0.001, respectively), and there was no significant difference between the two groups before and after electrolyte treatment.Conclusion ALSS After all, it is an effective and safe treatment method for the treatment of severe hepatitis, which can significantly reduce the case fatality rate and improve the survival rate.